Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome

Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome

The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that occurs naturally with aging drives a "field effect" predisposing normal tissues for cancer development. We propose that mutations in the cancer susceptibility genes BRCA1/2 might trigger "accelerated geroncogenesis" in breast and ovarian epithelia. By speeding up the rate at which the metabolic threshold...

Hereditary Breast-Ovarian Cancer Syndrome in Russia

Hereditary breast-ovarian cancer syndrome contributes to as much as 5-7% of breast cancer (BC) and 10-15% of ovarian cancer (OC) incidence. Mutations in the "canonical" genesBRCA1andBRCA2occur in 20-30% of affected pedigrees. In addition toBRCA1andBRCA2 mutations, germ-line lesions in theCHEK2,NBS1, andPALB2genes also contribute to familial BC clustering. The epidemiology of hereditary breast-o...

[Hereditary breast and ovarian cancer syndrome].

Population with hereditary breast and ovarian cancer syndrome, i.e. BRCA1/2 mutation carriers, are at higher risk of developing breast and ovarian cancer as well as other solid tumours such as pancreatic cancer, prostate cancer and melanoma. With the increasing experience, screening recommendations and preventive strategies including prophylactic surgery are being settled. Surveillance of women...

Hereditary Breast-Ovarian Cancer

Prophylactic Surgery in Hereditary Breast/Ovarian Cancer Syndrome

Drs. Levine and Gemignani have provided a comprehensive review of the literature regarding the management of patients with hereditary breast/ovarian cancer syndrome. As noted, over 200,000 new cases of breast cancer and 25,000 new cases of ovarian cancer are estimated for 2003.[1] Only a small portion of these cases will be hereditary; however, these are the cases that may benefit from preventi...